Antioxidant, antimicrobial, antiulcer and analgesic activities of nettle (Urtica dioica L.)

The study authors: İlhami Gülçin, Ö.İrfan Küfrevioǧlu, Münir Oktay, Mehmet Emin Büyükokuroǧlu.

Department of Chemistry, Faculty of Science and Arts, Atatürk University, 25240 Erzurum, Turkey, Department of Chemistry Education, Kazım Karabekir Education Faculty, Atatürk University, 25240 Erzurum, Turkey, Department of Pharmacology, Medical Faculty, Atatürk University, 25240 Erzurum, Turke

Antioxidant, antimicrobial, antiulcer and analgesic activities of nettle (Urtica dioica L.)

In this study, water extract of nettle (Urtica dioica L.) (WEN) was studied for antioxidant, antimicrobial, antiulcer and analgesic properties. The antioxidant properties of WEN were evaluated using different antioxidant tests, including reducing power, free radical scavenging, superoxide anion radical scavenging, hydrogen peroxide scavenging, and metal chelating activities.

WEN had powerful antioxidant activity. The 50, 100 and 250 μg amounts of WEN showed 39, 66 and 98% inhibition on peroxidation of linoleic acid emulsion, respectively, while 60 μg/ml of α-tocopherol, exhibited only 30% inhibition. Moreover, WEN had effective reducing power, free radical scavenging, superoxide anion radical scavenging, hydrogen peroxide scavenging, and metal chelating activities at the same concentrations. Those various antioxidant activities were compared to standard antioxidants such as butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), quercetin, and α-tocopherol. In addition, total phenolic compounds in the WEN were determined as pyrocatechol equivalent. WEN also showed antimicrobial activity against nine microorganisms, antiulcer activity against ethanol-induced ulcerogenesis and analgesic effect on acetic acid-induced stretching.



The original text taken from a:

http://www.sciencedirect.com/science/article/pii/S0378874103003490

Journal of Ethnopharmacology (Volume 90, Issues 2–3, February 2004, Pages 205–215)


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