Treatment of obstructive sleep apnea syndrome with a Kampo-formula, San’o-shashin-to: a case report

The study authors: Hisanaga A, Saitoh O, Fukuda H, Kurokawa K, Okabe A, Tachibana H, Hagino H, Mita T, Yamashita I, Tsutsumi M, Kurachi M, Itoh T..

Department of Neuropsychiatry, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.

The results of research on "Treatment of obstructive sleep apnea syndrome with a Kampo-formula, San’o-shashin-to: a case report" conducted by Hisanaga A, Saitoh O, Fukuda H, Kurokawa K, Okabe A, Tachibana H, Hagino H, Mita T, Yamashita I, Tsutsumi M, Kurachi M, Itoh T. (Psychiatry and Clinical Neurosciences (Volume 53, Issue 2, pages 303–305, April 1999)).

Treatment of obstructive sleep apnea syndrome with a Kampo-formula, San’o-shashin-to: a case report

The following describes a 76 year old male with obstructive sleep apnea syndrome successfully treated with a Kampo-formula, San’o-shashin-to (Formula: medicamentorum tres ad dispellendi cordis).

Polysomnography, performed before and after administration of San’o-shashin-to, revealed that the apnea index decreased from 11.1 events/hour to 4.1 events/hour, and that the apnea plus hypopnea index decreased from 18.4 events/hour to 10.7 events/hour. The patient was normo-weight (body mass index: 20.4 kg/m2), and events of sleep apnea and hypopnea were mostly noted during a non-rapid eye movement sleep. It is possible that San’o-shashin-to has some alleviating effects on the upper airway resistance during sleep.

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Akito Hisanaga – Department of Neuropsychiatry, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama.


The complete study "Treatment of obstructive sleep apnea syndrome with a Kampo-formula, San’o-shashin-to: a case report" (Hisanaga A, Saitoh O, Fukuda H, Kurokawa K, Okabe A, Tachibana H, Hagino H, Mita T, Yamashita I, Tsutsumi M, Kurachi M, Itoh T.) in pdf file format:



The original text taken from a:

http://www.ncbi.nlm.nih.gov/pubmed/10459719?dopt=AbstractPlus

Psychiatry and Clinical Neurosciences (Volume 53, Issue 2, pages 303–305, April 1999)


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