{"id":3662,"date":"2016-10-11T23:07:37","date_gmt":"2016-10-11T21:07:37","guid":{"rendered":"https:\/\/eco-supplements.com\/pl\/?p=3662"},"modified":"2019-10-28T20:14:41","modified_gmt":"2019-10-28T19:14:41","slug":"kwas-hydroksycytrynowy-hca","status":"publish","type":"post","link":"https:\/\/eco-supplements.com\/pl\/organiczne-zwiazki-chemiczne\/kwas-hydroksycytrynowy-hca\/","title":{"rendered":"Kwas hydroksycytrynowy HCA"},"content":{"rendered":"<p>Kwas hydroksycytrynowy (HCA &#8211; C<sub>6<\/sub>H<sub>8<\/sub>O<sub>8<\/sub>) to pochodna kwasu cytrynowego , kt\u00f3ry znajduje si\u0119 w r\u00f3\u017cnych ro\u015blinach, w tym tropikalnych <em>Garcinia Cambogia<\/em> i <em>Hibiscus Subdariffa<\/em><sup><small><a href=\"#cite-1\">[1]<\/a><\/small><\/sup>.<br \/>\n<!--more--><\/p>\n<h3>Izomery kwasu HCA<\/h3>\n<p>Istniej\u0105 cztery izomery kwasu HCA:<\/p>\n<ul>\n<li>(+) &#8211; i (-) &#8211; kwas hydroksycytrynowy,<\/li>\n<li>(+) &#8211; i (-) &#8211; kwas allo-hydroksycytrynowy.<\/li>\n<\/ul>\n<p>(-) &#8211; izomer kwasu hydroksycytrynowego, kt\u00f3ry znale\u017a\u0107 mo\u017cemy w <a href=\"https:\/\/eco-supplements.com\/pl\/garcinia-cambogia-gummi-gutta\/\">Garcinia Cambogia<\/a><sup><small><a href=\"#cite-2\">[2]<\/a><\/small><\/sup>.<\/p>\n<h2>Dzia\u0142anie biologiczne kwasu hydroksycytrynowego (HCA)<\/h2>\n<p>(-) &#8211; HCA jest konkurencyjnym inhibitorem liazy cytrynianu ATP, kt\u00f3ry przekszta\u0142ca si\u0119 z cytrynianu do <span class=\"\">szczawiooctanu<\/span> i acetylo-CoA<sup><small><a href=\"#cite-2\">[2]<\/a><\/small><\/sup>.<\/p>\n<p>Badania <a href=\"https:\/\/eco-supplements.com\/pl\/organiczne-zwiazki-chemiczne\/kwas-hydroksycytrynowy-hca\/\">HCA<\/a> na zwierz\u0119tach i laboratoryjne przynios\u0142y wyniki, kt\u00f3re wskazuj\u0105 na mo\u017cliwo\u015b\u0107 modulacji metabolizmu lipid\u00f3w<sup><small><a href=\"#cite-3\">[3]<\/a><\/small><\/sup>. Badacze s\u0105 podzieleni co do wp\u0142ywu HCA na utrat\u0119 wagi (<a href=\"https:\/\/eco-supplements.com\/pl\/naturalne-odchudzanie\/\">odchudzanie<\/a>) i zmniejszenie masy tkanki t\u0142uszczowej<sup><small><a href=\"#cite-4\">[4]<\/a><\/small><\/sup><sup><small><a href=\"#cite-10\">[10]<\/a><\/small><\/sup>.\u00a0Metaanaliza opublikowana w 2010 roku wykaza\u0142a, \u017ce <a href=\"https:\/\/eco-supplements.com\/pl\/organiczne-zwiazki-chemiczne\/kwas-hydroksycytrynowy-hca\/\">kwas hydroksycytrynowy<\/a> HCA ma dzia\u0142ania niepo\u017c\u0105dane na przew\u00f3d pokarmowy. Zastosowanie kwasu hydroksycytrynowego HCA jest przeciwwskazane u pacjent\u00f3w cierpi\u0105cych na zapalenie jelita grubego lub zapalnej choroby jelita grubego<sup><small><a href=\"#cite-5\">[5]<\/a><\/small><\/sup>.<\/p>\n<p>Naukowcy z University of Houston udowodnili, \u017ce kwas hydroksycytrynowy ma zdolno\u015b\u0107 rozpuszczania kryszta\u0142\u00f3w szczawianu wapnia, kt\u00f3ry jest sk\u0142adnikiem kamieni nerkowych u ludzi. Jest to niezwyk\u0142e odkrycie, poniewa\u017c mo\u017ce ono doprowadzi\u0107 do opracowania nowych lek\u00f3w na kamic\u0119 nerkow\u0105 u cz\u0142owieka<sup><small><a href=\"#cite-9\">[9]<\/a><\/small><\/sup>.<\/p>\n<hr \/>\n<h3 id=\"references\">Przypisy<\/h3>\n<ol>\n<li id=\"cite-1\"><small>Yamada T, Hida H, Yamada Y (2007). &#8222;Chemistry, physiological properties, and microbial production of hydroxycitric acid&#8221;. Appl. Microbiol. Biotechnol. 75 (5): 977\u201382.<\/small><\/li>\n<li id=\"cite-2\"><small> Jena et al 2002, Chemistry and Biochemistry of (\u2212)-Hydroxycitric Acid from Garcinia, Journal of Agricultural and Food Chemistry 50(1):10-22.<\/small><\/li>\n<li id=\"cite-3\"><small>Shara M, Ohia SE, Yasmin T, et al. (2003). &#8222;Dose- and time-dependent effects of a novel (\u2212)-hydroxycitric acid extract on body weight, hepatic and testicular lipid peroxidation, DNA fragmentation and histopathological data over a period of 90 days&#8221;. Mol. Cell. Biochem. 254 (1\u20132): 339\u201346.<\/small><\/li>\n<li id=\"cite-4\"><small>Heymsfield SB, Allison DB, Vasselli JR, Pietrobelli A, Greenfield D, Nunez C (1998). &#8222;Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial&#8221;. JAMA. 280 (18): 1596\u2013600.<\/small><\/li>\n<li id=\"cite-5\"><small> Igho O, Shao K, Rachel P, Barbara W, Edzard E (2011). &#8222;The Use of Garcinia Extract Hydroxycitric Acid as a Weight loss Supplement: A Systematic Review and Meta-Analysis of Randomised Clinical Trials&#8221;. J Obes. 2011 (622): 849.<\/small><\/li>\n<li id=\"cite-6\"><small>Saito M, Ueno M, Ogino S, Kubo K, Nagata J, Takeuchi M (2005). &#8222;High dose of Garcinia cambogia is effective in suppressing fat accumulation in developing male Zucker obese rats, but highly toxic to the testis&#8221;. Food Chem. Toxicol. 43 (3): 411\u20139.<\/small><\/li>\n<li id=\"cite-7\"><small>Madhusudan Soni Burdock Group (2005). &#8222;Garcinia cambogia toxicity is misleading&#8221;. Food and Chemical Toxicology. 43 (11): 1683\u20131684.<\/small><\/li>\n<li id=\"cite-8\"><small>Hayamizu, K; Tomi, H; Kaneko, I; Shen, M; Soni, MG; Yoshino, G (2008). &#8222;Effects of Garcinia cambogia extract on serum sex hormones in overweight subjects&#8221;. Fitoterapia. 79 (4): 255\u201361.<\/small><\/li>\n<li id=\"cite-9\"><small>Chung J, Granja I, Taylor M, Mpourmpakis G, Asplin J. &#8222;Molecular modifiers reveal a mechanism of pathological crystal growth inhibition&#8221;. Nature.<\/small><\/li>\n<li id=\"cite-10\"><small>ONAKPOYA, Igho; HUNG, Shao Kang; PERRY, Rachel; WIDER, Barbara; ERNST, Edzard. <span class=\"ExternalLinks\"><a title=\"The use of Garcinia extract (hydroxycitric acid) as a weight loss supplement: a systematic review and meta-analysis of randomised clinical trials\" href=\"https:\/\/the-best-supplements.com\/free_articles\/the-use-of-garcinia-extract-hydroxycitric-acid-as-a-weight-loss-supplement-a-systematic-review-and-meta-analysis-of-randomised-clinical-trials\/\" rel=\"noopener noreferrer\" target=\"_blank\">The use of Garcinia extract (hydroxycitric acid) as a weight loss supplement: a systematic review and meta-analysis of randomised clinical trials<\/a><\/span>. Journal of obesity, 2010, 2011: 44.<\/small><\/li>\n<li id=\"cite-11\"><small><span class=\"InternalLinks\"><a href=\"https:\/\/eco-supplements.com\/scientific\/evaluation-of-the-pharmacotherapeutic-efficacy-of-garcinia-cambogia-plus-amorphophallus-konjac-for-the-treatment-of-obesity\/\" rel=\"nofollow\">Evaluation of the pharmacotherapeutic efficacy of Garcinia cambogia plus Amorphophallus konjac for the treatment of obesity<\/a><\/span>, Carlos A. R. Vasques, Simone Rossetto, Graziele Halmenschlager, Rafael Linden, Eliane Heckler, Maria S. Poblador Fernandez, Jos\u00e9 L. Lancho Alonso, Phytotherapy Research Volume 22, Issue 9, pages 1135\u20131140, September 2008<\/small><\/li>\n<li id=\"cite-12\"><small><span class=\"InternalLinks\"><a href=\"https:\/\/eco-supplements.com\/scientific\/garcinia-cambogia-hydroxycitric-acid-as-a-potential-antiobesity-agent-a-randomized-controlled-trial\/\" rel=\"nofollow\">Garcinia cambogia (Hydroxycitric Acid) as a Potential Antiobesity Agent: A Randomized Controlled Trial<\/a><\/span>, Steven B. Heymsfield, MD; David B. Allison, PhD; Joseph R. Vasselli, PhD; Angelo Pietrobelli, MD; Debra Greenfield, MS, RD; Christopher Nunez, MEd, JAMA &#8211; The Journal of the American Medical Association (1998;280(18):1596-1600)<\/small><\/li>\n<li id=\"cite-99\"><small>Kwas hydroksycytrynowy (Portal ABC Zdrowie) &#8211; <span class=\"ExternalLinks\"><a href=\"https:\/\/portal.abczdrowie.pl\/kwas-hydroksycytrynowy\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">https:\/\/portal.abczdrowie.pl\/kwas-hydroksycytrynowy<\/a><\/span>.<\/small><\/li>\n<li id=\"cite-100\"><small>Hydroxycitric acid (Wikipedia) &#8211; <span class=\"ExternalLinks\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Hydroxycitric_acid\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">https:\/\/en.wikipedia.org\/wiki\/Hydroxycitric_acid<\/a><\/span>.<\/small><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Kwas hydroksycytrynowy (HCA &#8211; C6H8O8) to pochodna kwasu cytrynowego , kt\u00f3ry znajduje si\u0119 w r\u00f3\u017cnych ro\u015blinach, w tym tropikalnych Garcinia Cambogia i Hibiscus Subdariffa[1].<\/p>\n","protected":false},"author":1,"featured_media":3664,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[808],"tags":[38,39,897,900,899,40,898],"class_list":["post-3662","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-organiczne-zwiazki-chemiczne","tag-garcinia-cambogia","tag-hca","tag-hibiscus-subdariffa","tag-kamica-nerkowa","tag-kamienie-nerkowe","tag-kwas-hydroksycytrynowy","tag-szczawian-wapnia"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/eco-supplements.com\/pl\/wp-json\/wp\/v2\/posts\/3662","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/eco-supplements.com\/pl\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/eco-supplements.com\/pl\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/eco-supplements.com\/pl\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/eco-supplements.com\/pl\/wp-json\/wp\/v2\/comments?post=3662"}],"version-history":[{"count":28,"href":"https:\/\/eco-supplements.com\/pl\/wp-json\/wp\/v2\/posts\/3662\/revisions"}],"predecessor-version":[{"id":10703,"href":"https:\/\/eco-supplements.com\/pl\/wp-json\/wp\/v2\/posts\/3662\/revisions\/10703"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/eco-supplements.com\/pl\/wp-json\/wp\/v2\/media\/3664"}],"wp:attachment":[{"href":"https:\/\/eco-supplements.com\/pl\/wp-json\/wp\/v2\/media?parent=3662"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/eco-supplements.com\/pl\/wp-json\/wp\/v2\/categories?post=3662"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/eco-supplements.com\/pl\/wp-json\/wp\/v2\/tags?post=3662"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}