An unusual lectin from stinging nettle (Urtica dioica) rhizomes

The study authors: Peumans Willy J., De Ley Marc, Broekaert Willem F..

An unusual lectin from stinging nettle (Urtica dioica) rhizomes

An unusual lectin has been isolated from stinging nettle (Urtica dioica L.) rhizomes. It is a small (8.5 kDa) monomeric protein with high contents of glycine, cysteine and tryptophan.

The Urtica dioica agglutinin (UDA) is not blood group-specific and is specifically inhibited by N-acetylglucosamine oligomers. As compared to other plant lectins, UDA has a very low specific agglutination activity. Nevertheless, it induces HulFN-γ in human lymphocytes at concentrations comparable to those of other inducers.

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Peumans, Willy J., Marc De Ley, and Willem F. Broekaert. "An unusual lectin from stinging nettle (Urtica dioica) rhizomes." FEBS letters 177.1 (1984): 99-103.