Instituto de Ciências da Saúde, Ciências Farmacêuticas, Centro Universitário Feevale, RS-239, 2755, 93352-000 Novo Hamburgo-RS, Brazil Programa de doctorado en Ciencias Aplicadas a la Actividad Física y el Deporte, Departamento de Ciencias Morfológicas, Facultad de Medicina, Universidad de Córdoba, Avda. Menéndez Pidal, s/n., 14004 Córdoba, Spain
Hydroxycitric acid (HCA), the main compound of Garcinia cambogia extract, is a competitive blocker of ATP-citrate-lyase, presenting a potential inhibition of fatty acid biosynthesis.
Glucomannan fibers, abundant in Amorphophallus konjac, seem to reduce the absorption kinetics of dietary fat. Therefore, the aim of this double-blind randomized study was to evaluate the pharmacotherapeutic efficacy of standardized extracts of Garcinia Cambogia (52.4% HCA) plus A. konjac (94.9% glucomannan) in the treatment of obesity. Fifty-eight obese subjects (BMI 30.0–39.9 kg/m2) were assigned to the placebo group (n = 26) or the treatment group (n = 32); no dietary restrictions were applied. Over a 12-week period, subjects were given daily doses of either Garcinia (2.4 g) plus Konjac (1.5 g) or placebo prior to their main meals (3 times/day). Before the start of treatment, and every 4 weeks thereafter, the following were recorded: height, weight, circumferences and body composition, resting energy expenditure (REE), lipid profile and glucose levels.
The treatment had no significant effect on anthropometric parameters, REE, triglycerides or glucose levels.However, a significant reduction was observed in total cholesterol (−32.0 ± 35.1 mg/dL) and LDL-c levels (−28.7 ± 32.7 mg/dL) in the treated group, the final levels being significantly lower than those of the placebo group (p = 0.008 and p = 0.020, respectively). The results obtained suggest that the treatment had a significant hypocholesterolemic effect, without influencing the anthropometric or calorimetric parameters tested. Copyright © 2008 John Wiley & Sons, Ltd.
Obesity is a chronic disease which has become highly prevalent in many present-day societies; it is also a major risk factor for a number of pathologies associated with high mortality, such as high blood pressure, stroke and ischemic heart disease. The link between obesity and cardiovascular disease has been clearly established; excess weight is a risk factor for heart disease because it is also associated with metabolic disorders, including dyslipidemia, type 2 diabetes and metabolic syndrome (Bray, 2004; Carr et al., 2004).
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Phytotherapy Research Volume 22, Issue 9, pages 1135–1140, September 2008