Evaluation of the pharmacotherapeutic efficacy of Garcinia cambogia plus Amorphophallus konjac for the treatment of obesity

The study authors: Carlos A. R. Vasques, Simone Rossetto, Graziele Halmenschlager, Rafael Linden, Eliane Heckler, Maria S. Poblador Fernandez, José L. Lancho Alonso.

Instituto de Ciências da Saúde, Ciências Farmacêuticas, Centro Universitário Feevale, RS-239, 2755, 93352-000 Novo Hamburgo-RS, Brazil Programa de doctorado en Ciencias Aplicadas a la Actividad Física y el Deporte, Departamento de Ciencias Morfológicas, Facultad de Medicina, Universidad de Córdoba, Avda. Menéndez Pidal, s/n., 14004 Córdoba, Spain

Evaluation of the pharmacotherapeutic efficacy of Garcinia cambogia plus Amorphophallus konjac for the treatment of obesity

Hydroxycitric acid (HCA), the main compound of Garcinia cambogia extract, is a competitive blocker of ATP-citrate-lyase, presenting a potential inhibition of fatty acid biosynthesis.

Glucomannan fibers, abundant in Amorphophallus konjac, seem to reduce the absorption kinetics of dietary fat. Therefore, the aim of this double-blind randomized study was to evaluate the pharmacotherapeutic efficacy of standardized extracts of Garcinia Cambogia (52.4% HCA) plus A. konjac (94.9% glucomannan) in the treatment of obesity. Fifty-eight obese subjects (BMI 30.0–39.9 kg/m2) were assigned to the placebo group (n = 26) or the treatment group (n = 32); no dietary restrictions were applied. Over a 12-week period, subjects were given daily doses of either Garcinia (2.4 g) plus Konjac (1.5 g) or placebo prior to their main meals (3 times/day). Before the start of treatment, and every 4 weeks thereafter, the following were recorded: height, weight, circumferences and body composition, resting energy expenditure (REE), lipid profile and glucose levels.

The treatment had no significant effect on anthropometric parameters, REE, triglycerides or glucose levels.However, a significant reduction was observed in total cholesterol (−32.0 ± 35.1 mg/dL) and LDL-c levels (−28.7 ± 32.7 mg/dL) in the treated group, the final levels being significantly lower than those of the placebo group (p = 0.008 and p = 0.020, respectively). The results obtained suggest that the treatment had a significant hypocholesterolemic effect, without influencing the anthropometric or calorimetric parameters tested. Copyright © 2008 John Wiley & Sons, Ltd.

Obesity is a chronic disease which has become highly prevalent in many present-day societies; it is also a major risk factor for a number of pathologies associated with high mortality, such as high blood pressure, stroke and ischemic heart disease. The link between obesity and cardiovascular disease has been clearly established; excess weight is a risk factor for heart disease because it is also associated with metabolic disorders, including dyslipidemia, type 2 diabetes and metabolic syndrome (Bray, 2004; Carr et al., 2004).

Efect of Garcinia Cambogia

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Phytotherapy Research Volume 22, Issue 9, pages 1135–1140, September 2008