The cannabinoid system and immune modulation

The study authors: Thomas W. Klein, Cathy Newton, Kellie Larsen, Lily Lu, Izabella Perkins, Liang Nong, Herman Friedman.

University of South Florida, Department of Medical Microbiology & Immunology, Tampa.

The results of research on "The cannabinoid system and immune modulation" conducted by Thomas W. Klein, Cathy Newton, Kellie Larsen, Lily Lu, Izabella Perkins, Liang Nong, Herman Friedman (Klein, Thomas W., et al. "The cannabinoid system and immune modulation." Journal of leukocyte biology 74.4 (2003): 486-496.).

The cannabinoid system and immune modulation

Studies on the effects of marijuana smoking have evolved into the discovery and description of the endocannabinoid system. To date, this system is composed of two receptors, CB1 and CB2, and endogenous ligands including anandamide, 2‐arachidonoyl glycerol, and others. CB1 receptors and ligands are found in the brain as well as immune and other peripheral tissues.

Conversely, CB2 receptors and ligands are found primarily in the periphery, especially in immune cells. Cannabinoid receptors are G protein‐coupled receptors, and they have been linked to signaling pathways and gene activities in common with this receptor family. In addition, cannabinoids have been shown to modulate a variety of immune cell functions in humans and animals and more recently, have been shown to modulate T helper cell development, chemotaxis, and tumor development. Many of these drug effects occur through cannabinoid receptor signaling mechanisms and the modulation of cytokines and other gene products. It appears the immunocannabinoid system is involved in regulating the brain‐immune axis and might be exploited in future therapies for chronic diseases and immune deficiency.

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The complete study "The cannabinoid system and immune modulation" (Thomas W. Klein, Cathy Newton, Kellie Larsen, Lily Lu, Izabella Perkins, Liang Nong, Herman Friedman) in pdf file format:


Klein, Thomas W., et al. "The cannabinoid system and immune modulation." Journal of leukocyte biology 74.4 (2003): 486-496.