Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer

The study authors: EWAN CAMERON, LINUS PAULING.

Vale of Leven District General Hospital, Loch Lomondside, G83 OUA, Scotland, Linus Pauling Institute of Science and Medicine, 2700 Sand Hill Road, Menlo Park, California 94025

The results of research on "Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer" conducted by EWAN CAMERON, LINUS PAULING (E Cameron and L Pauling, Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer PNAS 1976 73 (10) 3685-3689).

Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer

Ascorbic acid metabolism is associated with a number of mechanisms known to be involved in host resistance to malignant disease.

Cancer patients are significantly depleted of ascorbic acid, and in our opinion this demonstrable biochemical characteristic indicates a substantially increased requirement and utilization of this substance to potentiate these various host resistance factors. The results of a clinical trial are presented in which 100 terminal cancer patients were given supplemental ascorbate as part of their routine management. Their progress is compared to that of 1000 similar patients treated identically, but who received no supplemental ascorbate. The mean survival time is more than 4.2 times as great for the ascorbate subjects (more than 210 days) as for the controls (50 days). Analysis of the survival-time curves indicates that deaths occur for about 90% of the ascorbate-treated patients at one-third the rate for the controls and that the other 10% have a much greater survival time, averaging more than 20 times that for the controls. The results clearly indicate that this simple and safe form of medication is of definite value in the treatment of patients with acvanced cancer.


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The complete study "Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer" (EWAN CAMERON, LINUS PAULING) in pdf file format:



The original text taken from a:

http://www.pnas.org/content/73/10/3685.short

E Cameron and L Pauling, Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer PNAS 1976 73 (10) 3685-3689