Department of Biochemistry, Faculty of Science, University of Yaoundé I, B.P. 812, Yaoundé, Cameroon, Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, B.P. 812, Yaoundé, Cameroon, Department of Plant Science, University of Pretoria, Pretoria 0002, South Africa
The antimicrobial activity of the methanolic extract from the stem bark of Irvingia gabonensis (IGM), fractions and compounds isolated from IGM [3-friedelanone (1), betulinic acid (2), oleanolic acid (3), 3,3′,4′-tri-O-methylellagic acid (4), 3,4-di-O-methylellagic acid (5) and hardwickiic acid (6)] was evaluated against Gram-positive bacteria (6 species), Gram-negative bacteria (13 species) and three Candida species using dilution methods for the determination of the minimal inhibition concentration (MIC) and the minimal microbicidal concentration (MMC).
From the obtained results, IGM prevented the growth of all the species of microorganisms tested at a concentration limit of 312.50 μg/ml. Compounds 4–6 also inhibited the growth of all the tested microbial species while compounds 1–3 showed selective activities. The lowest MIC values (78.12 μg/ml) were obtained with IGM on 13 of the 22 microorganisms tested. The corresponding value of 1.22 μg/ml (4.26 μM) for compounds was recorded with compound 6 on Neisseria gonorrhoeae. The obtained results confirmed the use of Irvingia gabonensis in the treatment of bacterial and fungal infections.
The original text taken from a:
Antimicrobial activity of the methanolic extract, fractions and compounds from the stem bark of Irvingia gabonensis (Ixonanthaceae), Victor Kuetea, Ghislain Fotso Wabo, Bathélémy Ngameni, Armelle Tsafack Mbaveng, Robert Metuno, François-Xavier Etoa, Bonaventure Tchaleu Ngadjui, Véronique Penlap Beng, J.J. Marion Meyer, Namrita Lall, Journal of Ethnopharmacology, Volume 114, Issue 1, 8 October 2007, Pages 54–60